Extremely potent inhibitor of Rho kinase II (ROCK-II)1,2 - it displayed greater selectivity and potency compared to Y-27632 (IC50s: ROCK I = 52 pM/ROCK II = 1 pM, Y-27632 IC50s: ROCK I = 71 nM/ROCK II = 46 nM)3. Chroman 1, used in conjunction with tran
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