T-10418 is a potent (EC50 = 820 nM) and selective (against 300 non-olfactory GPCRs) agonist of G2 accumulation protein (G2A, GPR132). At 100 nM, T-10418 resulted in 244% TRPV1 sensitization in mouse sensory neurons. T-10418 is an interesting new chemical
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