Potent (IC50 = 10 nM IFN-g/LPS-stimulated human PMBCs, IC50 = 1 nM in IFN-g/SAC-stimulated human PMBCs) IL-12/IL-23 inhibitor downregulating both at the transcriptional level. Suppresses Th1 but not Th2 immune response.1 Inhibition was also observed in
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