UNC0224 is a potent inhibitor of histone methyltransferases G9a / EHMT2 (IC50 = 15 nM) and GLP / EHMT1 (IC50 ~ 39 nM) but not SET7/9 and SET8.1-3 Has been employed, as part of a small molecule cocktail, to reprogram somatic cells to pluripotent stem cell
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