GW788388, CAS [[452342-67-5]]

Product Overview

• Article Name: GW788388, CAS [[452342-67-5]]
• Biozol Catalog Number: FBM-10-5521
• Supplier Catalog Number: 10-5521
• Alternative Catalog Number: FBM-10-5521-5MG,FBM-10-5521-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien

Product Description

TGF-ß receptor kinase inhibitor

Product Properties

• Molecular Weight: 425.49
• Purity: 98% by HPLC NMR (Conforms)
• Form: Off-white solid
• CAS Number: [452342-67-5]
• Formula: C25H23N5O2

Application Notes

• Application Notes: Potent inhibitor of TGF-beta receptor kinases ALK4, ALK5 (IC50=18 nM), ALK7, and TGFbetaRII, but not BMP type II receptor kinase.1,2 Blocks TGF-beta-mediated signaling, including collagen type I and VEGF, in turn reducing fibrosis and angiogenesis in various mous