This gene encodes a member of the Kunitz-type serine proteinase inhibitor family. The protein can inhibit a variety of serine proteases including factor VIIa/tissue factor, factor Xa, plasmin, trypsin, chymotryspin and plasma kallikrein. This gene has be
Reconstitute with 100 mM NaHCO3 and 500 mM NaCl (pH8.3) to 0.1-1.0 mg/mL. Do not vortex. Lyophilized from 100 mM NaHCO3 (pH 8.3) with 500 mM NaCl, 1 mM EDTA, 1 mM DTT, 0.01% SKL, 5% Trehalose, ProClin 300.
Expression System:
E. coli
Form:
Lyophilized powder
Sequence:
N-terminal His-Tag, Asp23~Phe235 (NP_001257932.1)
Application Notes:
Tissue Factor Pathway Inhibitor 2 (TFPI2) takes part in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. TFPI2 does not have any influence on thrombin. TFPI2 also can inhibit
GTX00278-pro Functional Assay Image
Hydrolysis assay on gelatin (1 mg/ml) with nonreducing conditions induced by various concentrations of GTX00278-pro Human TFPI2 protein (active). MMP-2 protein can be inhibited by Human TFPI2 protein (active) at least 5 μg/ml.
WB analysis of GTX00278-pro Human TFPI2 protein (active).
SDS-PAGE analysis of GTX00278-pro Human TFPI2 protein (active).
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