JNJ-40418677 is an orally active modulator of gamma-secretase, can cross the blood-brain barrier. JNJ-40418677 inhibits Abeta42 and NS2B-NS3 protease, with IC50s of 200 nM and 3.9 µM, respectively. JNJ-40418677 displays good biological tolerance, can be use for
Molecular Weight:
480.44
Purity:
99
CAS Number:
[1146594-87-7]
Formula:
C26H22F6O2
Target:
Amyloid-beta,gamma-secretase
Application Notes:
Reference compound
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