GS143 is a selec-tive IkappaBalpha ubiquitination inhibitor with an IC50 of 5.2 µM for SCFbetaTrCP1-mediated IkappaBalpha ubiquitylation. GS143 sup-presses NF-kappaB acti-va-tion and tran-scrip-tion of tar-get genes and does not inhibit proteasome activity. GS143 has anti-asth
Molecular Weight:
466.46
Purity:
99.09
CAS Number:
[916232-21-8]
Formula:
C28H19FN2O4
Target:
E1/E2/E3 Enzyme,IKK,NF-kappaB
Application Notes:
Reference compound
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