Icerguastat (Sephin1), a derivative of Guanabenz lacking the alpha2-adrenergic activity, is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A). Icerguastat inhibits eIF2alpha dephosphorylation, thereby prolonging the protective response.
Molecular Weight:
196.64
Purity:
99.90
CAS Number:
[951441-04-6]
Formula:
C8H9ClN4
Target:
Phosphatase
Application Notes:
Reference compound
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