K20 is a potent and selective KRas G12C inhibitor with an IC50 of 1.16 µM. K20 shows anticancer activity in H358 cells (IC50= 0.78 µM). K20 decreases the levels of phosphorylated Erk and leads to cancer cell apoptosis. K20 suppresses NCI-H358 tumor growt
Molecular Weight:
543.34
Formula:
C24H20Cl2F4N4O2
Target:
Apoptosis,ERK,Ras
Application Notes:
Reference compound
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