FzM1 is a negative allosteric modulator (NAM) of Frizzled receptor FZD4. FzM1 reduces WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=-6.2). FzM1 binds to an allosteric binding site located in intracellular loop 3 (ICL3) of FZD4 and al
Molecular Weight:
360.43
Purity:
98.62
CAS Number:
[1680196-54-6]
Formula:
C21H16N2O2S
Target:
Wnt,beta-catenin
Application Notes:
Reference compound
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