BRD0705 is a potent, paralog selective and orally active GSK3alpha inhibitor with an IC50 of 66 nM and a Kd of 4.8 µM. BRD0705 displays increased selectivity for GSK3alpha (8-fold) versus GSK3beta (IC50 of 515 nM). BRD0705 can be used for acute myeloid leukemia (AM
Molecular Weight:
321.42
Purity:
99.80
CAS Number:
[2056261-41-5]
Formula:
C20H23N3O
Target:
GSK-3
Application Notes:
Reference compound
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