C25-140, a first-in-class, orally active, and fairly selective TRAF6-Ubc13 inhibitor, directly binds to TRAF6, and blocks the interaction of TRAF6 with Ubc13. C25-140 lowers TRAF6 activity, reduces NF-kappaB activation, and combats autoimmunity[1].
Molecular Weight:
457.57
Purity:
99.86
CAS Number:
[1358099-18-9]
Formula:
C26H31N7O
Target:
E1/E2/E3 Enzyme,TNF Receptor
Application Notes:
Reference compound
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