CLZ-8 (Compound 8) is an orally active Mcl-1-PUMA interface inhibitor, with a Ki of 0.3 µM. CLZ-8 exhibits dual activity on reduce PUMA-dependent apoptosis while deactivating Mcl-1-mediated anti-apoptosis in cancer cells[1].
Molecular Weight:
393.50
Purity:
99.85
CAS Number:
[678158-55-9]
Formula:
C22H23N3O2S
Target:
Apoptosis,Bcl-2 Family
Application Notes:
Reference compound
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