ML347 (LDN193719) is a highly selective ALK1/ALK2 inhibitor. ML347 has IC50 values of 46 and 32 nM against ALK1 and ALK2, respectively, >300-fold selective over ALK3. ML347 block the phosphorylation of Smad1/5 by TGF-beta1[1][2].
Molecular Weight:
352.39
Purity:
99.89
CAS Number:
[1062368-49-3]
Formula:
C22H16N4O
Target:
TGF-beta Receptor
Application Notes:
Reference compound
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