AZ12601011 is an orally active, selective TGFBR1 kinase inhibitor with an IC50 of 18 nM and a Kd of 2.9 nM. AZ12601011 inhibits phosphorylation of SMAD2 via selectively inhibiting ALK4, TGFBR1, and ALK7. AZ12601011 inhibits mammary tumor growth [1].
Molecular Weight:
313.36
Purity:
99.88
CAS Number:
[2748337-86-0]
Formula:
C19H15N5
Target:
TGF-beta Receptor
Application Notes:
Reference compound
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