RO5353 is an orally active inhibitor for p53-MDM2 with an IC50 of 7 nM for MDM2. RO5353 inhibits the proliferation of wild-type p53 cancer cells with an average IC50 of 7 nM. RO5353 exhibits antitumor efficacy and good pharmacokinetic characteristics in
Molecular Weight:
619.53
CAS Number:
[1360821-61-9]
Formula:
C29H29Cl2FN4O4S
Target:
MDM-2/p53
Application Notes:
Reference compound
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