GNE-987 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. GNE-987 exhibits picomolar cell BRD4 degradation activity (DC50=0.03 nM for EOL-1 AML cell line). GNE-987 binds equipotently to the BD1 and BD2 bromodomains of BRD4 with low nanomol
Molecular Weight:
1096.31
Purity:
99.91
CAS Number:
[2417371-71-0]
Formula:
C56H67F2N9O8S2
Target:
Epigenetic Reader Domain,PROTACs
Application Notes:
Reference compound
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