PROTAC PD-1/PD-L1 degrader-1, a PD-1/PD-L1 PROTAC based on Cereblon E3 ligand, inhibits PD-1/PD-L1 interaction with an IC50 of 39.2 nM. PROTAC PD-1/PD-L1 degrader-1 significantly restores the immunity repressed in a co-culture model of Hep3B/OS-8/hPD-L1
Molecular Weight:
1076.59
Purity:
99.52
CAS Number:
[2447066-37-5]
Formula:
C59H58ClN7O11
Target:
PD-1/PD-L1,PROTACs
Application Notes:
Reference compound
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