TNF-alpha-IN-2 is a potent and orally active inhibitor of tumor necrosis factor alpha (TNFalpha), with an IC50 of 25 nM in the HTRF assay. TNF-alpha-IN-2 distorts the TNFalpha trimer upon binding, leading to aberrant signaling when the trimer binds to TNFR1. TNF-alpha-IN-2
Molecular Weight:
494.92
Purity:
98.12
CAS Number:
[2074702-04-6]
Formula:
C25H21ClF2N6O
Target:
TNF Receptor
Application Notes:
Reference compound
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