GSK717 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor. GSK717 inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling, with an IC50 of 400 nM for MDP-stimulated IL-8 secretion in HEK293/hNOD2 cells[1].
Molecular Weight:
452.55
Purity:
99.88
CAS Number:
[1595278-21-9]
Formula:
C28H28N4O2
Target:
NOD-like Receptor (NLR)
Application Notes:
Reference compound
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