ALV2 is a potent and selective Helios degrader. ALV2 binds CRBN, with an IC50 of 0.57 µM. Helios is the zinc-finger transcription factor that can maintain a stable Treg cell phenotype in the inflammatory tumor microenvironment[1].
Molecular Weight:
523.97
Purity:
98.07
CAS Number:
[2438124-95-7]
Formula:
C26H26ClN5O5
Target:
Ligands for E3 Ligase,Molecular Glues
Application Notes:
Reference compound
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