Tazemetostat, CAS [[1403254-99-8]]

Product Overview

• Article Name: Tazemetostat, CAS [[1403254-99-8]]
• Biozol Catalog Number: MCE-HY-13803
• Supplier Catalog Number: HY-13803
• Alternative Catalog Number: MCE-HY-13803-500MG,MCE-HY-13803-1MG,MCE-HY-13803-10MG,MCE-HY-13803-1G,MCE-HY-13803-100MG,MCE-HY-13803-50MG,MCE-HY-13803-10MMX1ML,MCE-HY-13803-200MG,MCE-HY-13803-5MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien
• Alternative Names: EPZ-6438, E-7438

Product Description

Tazemetostat (EPZ-6438) is a potent, selective and orally available EZH2 inhibitor. Tazemetostat inhibits the activity of human polycomb repressive complex 2 (PRC2)-containing wild-type EZH2 with a Ki value of 2.5 nM. Tazemetostat inhibits EZH2 with IC50s of 11 and 16 nM in peptide assay and nucleosome assay, respectively. Tazemetostat inhibits rat EZH2 with an IC50 of 4 nM. Tazemetostat also inhibits EZH1 with an IC50 of 392 nM. Tazemetostat induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells[1].

Product Properties

• Molecular Weight: 572.74
• Purity: 99.93
• CAS Number: [1403254-99-8]
• Formula: C34H44N4O4
• Target: Apoptosis,Histone Methyltransferase

Application Notes

• Application Notes: MCE Product type: Reference compound