XY153 (compound 8l) is a BD2-selective BET inhibitor and selectively binds to BRD4 BD2. XY153 binds to BRD4 BD2, BRD3 BD2 and BRD2 BD2 with IC50s of 0.79, 5.31 and 5.09 nM, respectively. XY153 shows potent antiproliferative activity against multiple tumo
Molecular Weight:
555.64
CAS Number:
[2933176-32-8]
Formula:
C33H34FN3O4
Target:
Epigenetic Reader Domain
Application Notes:
Reference compound
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