GEM144 is a potent and orally active DNA polymerase alpha (POLA1) and HDAC 11 dual inhibitor. GEM144 induces acetylation of p53, activation of p21, G1/S cell cycle arrest, and apoptosis. GEM144 has significant antitumor activity in human orthotopic malignant
Molecular Weight:
461.55
CAS Number:
[2487526-28-1]
Formula:
C28H31NO5
Target:
Apoptosis,DNA/RNA Synthesis,HDAC
Application Notes:
Reference compound
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