MIR002 is a potent and orally active DNA polymerase alpha (POLA1) and HDAC 11 dual inhibitor. MIR002 induces acetylation of p53, activation of p21, G1/S cell cycle arrest, and apoptosis. MIR002 shows significant antitumor activity in vivo[1].
Molecular Weight:
447.52
CAS Number:
[2217671-64-0]
Formula:
C27H29NO5
Target:
Apoptosis,DNA/RNA Synthesis,HDAC
Application Notes:
Reference compound
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