MS143 is a potent AKT degrader (DC50=46 nM and GI50=0.8 µM in PC3 cells). MS143 induces rapid and robust AKT degradation in a concentration- and time-dependent manner via hijacking the ubiquitin-proteasome system. MS143 can suppress cancer cell growth[1]
Molecular Weight:
1121.87
CAS Number:
[2376137-41-4]
Formula:
C59H81ClN12O6S
Target:
Akt
Application Notes:
Reference compound
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