JH-XVII-10 is a potent, selective and orally active DYRK1A and DYRK1B inhibitor with IC50s of 3 nM and 5 nM for DYRK1A and DYRK1B, respectively. JH-XVII-10 shows antitumor efficacy in neck squamous cell carcinoma (HNSCC) cell lines[1].
Molecular Weight:
486.42
Formula:
C22H18F4N8O
Target:
Apoptosis,DYRK
Application Notes:
Reference compound
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