Divarasib (GDC-6036) is an orally bioavailable, highly potent, and selective KRAS G12C inhibitor with an IC50 of <0.01 µM. Divarasib covalently binds to the switch II (SW-II) pocket of KRAS G12C and irreversibly locks it in the inactive GDP-bound state.
Molecular Weight:
622.06
Purity:
99.46
CAS Number:
[2417987-45-0]
Formula:
C29H32ClF4N7O2
Target:
Ras
Application Notes:
Reference compound
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