RIPK3-IN-3 (compound 20) is a selective inhibitor of RIP kinase RIPK3 (IC50=10 nM). RIPK3 mediates the phosphorylation of Mixed Lineage Kinase (MLKL) and causes necroptosis, while RIPK3-IN-3 inhibits p-MLKL oligomerization and thereby inhibits necroptosi
Molecular Weight:
305.36
Formula:
C16H11N5S
Target:
Mixed Lineage Kinase,RIP kinase
Application Notes:
Reference compound
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