AD4 is an artemisinin derivative that is a proteolytic targeting chimera (PROTAC) targeting PCLAF. AD4 can effectively degrade PCLAF in RS4,11 cells (IC50: 0.6 nM), thereby activating the p21/Rb axis and exerting anti-tumor activity. AD4 also prolonged s
Molecular Weight:
1035.23
Purity:
98.01
CAS Number:
[2918262-09-4]
Formula:
C55H78N4O15
Target:
PROTACs
Application Notes:
Reference compound
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