Akt/NF-kappaB/MAPK-IN-1 (compound 2m) is a potent and orally active inhibitor against NO (IC50=7.70 µM) with no significant toxicity. Akt/NF-kappaB/MAPK-IN-1 shows anti-inflammatory activity by inhibiting Akt/NF-kappaB and MAPK signaling pathways[1].
