AV123 (compound 12) is a non-cytotoxic RIPK1 inhibitor (IC50=12.12 µM). AV123 blocks the TNF-alpha-induced necroptotic (EC50=1.7 µM) but not the apoptotic cell death. AV123 can be used in the study of necrotic chronic conditions such as ischemia-reperfusion
Molecular Weight:
234.25
Purity:
99.60
CAS Number:
[233605-81-7]
Formula:
C11H14N4O2
Target:
RIP kinase
Application Notes:
Reference compound
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