EM127 (compound 11c) is a SMYD3 covalent inhibitor with high selectivity, high affinity (KD=13 µM) and site-specificity. EM127 effectively inhibits ERK1/2 phosphorylation and reduces transcriptional regulation of SMYD3 target genes. EM127 effectively and prolongedly impairs methyltransferase activity. EM127 can be used in cancer research, particularly in SMYD3 positive tumours[1].
Molecular Weight:
311.76
Purity:
99.94
CAS Number:
[1886879-71-5]
Formula:
C14H18ClN3O3
Target:
Histone Methyltransferase
Application Notes:
MCE Product type: Reference compound
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