APE1-IN-2 (compound AP1) is a Pt(IV) proagent, targeting a critical BER protein, apurinic/apyrimidinic endonuclease 1 (APE1). APE1-IN-2 shows anticancer activity. APE1-IN-2 induces intracellular accumulation of platinum and activates DNA damage response
Molecular Weight:
522.21
CAS Number:
[2923433-95-6]
Formula:
C9H12Cl2N4O5Pt
Target:
Apoptosis,MDM-2/p53
Application Notes:
Reference compound
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