GK444 (Compound 15a) is a HDAC1/2 inhibitor (IC50: 100 and 92 nM for HDAC1/2 respectively). GK444 inhibits Caco-2 cells with IC50 of 4.1 µM. GK444 also reduces TGF-beta1 induced COL1A1 mRNA levels in primary normal human lung fibroblasts. GK444 inhibits Ble
Molecular Weight:
548.63
CAS Number:
[3032392-39-2]
Formula:
C33H32N4O4
Target:
HDAC
Application Notes:
Reference compound
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