GDC-0623 (RG 7421) is a potent, ATP-uncompetitive inhibitor of MEK1 (Ki=0.13 nM, +ATP), and displays 6-fold weaker potency against HCT116 (KRAS (G13D), EC50=42 nM) versus A375 (BRAFV600E, EC50=7 nM).
Molecular Weight:
456.21
Purity:
99.15
CAS Number:
[1168091-68-6]
Formula:
C16H14FIN4O3
Target:
Apoptosis,MEK
Application Notes:
Reference compound
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