EGFR/AURKB-IN-1 (compound 7) is a dual-targeted EGFR/AURKB inhibitor, and inhibits the phpsphorylations of L858R EGFR and AURKB with IC50s of 0.07 and 1.1, respectively. EGFR/AURKB-IN-1 occupies the hydrophobic region I or the alphaC-helix out pocket of EGFR
Molecular Weight:
396.44
CAS Number:
[3008543-34-5]
Formula:
C23H20N6O
Target:
Aurora Kinase,EGFR
Application Notes:
Reference compound
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