JH-II-127 is an orally active, highly potent, selective and brain-permeable LRRK2 inhibitor, with IC50s of 6, 2 and 48 nM for wild-type LRRK2 and LRRK2-G2019S and mutant LRRK2-A2016T. JH-II-127 inhibits Ser935 phosphorylation in all tissues of mice, incl
Molecular Weight:
416.86
Purity:
98
CAS Number:
[1700693-08-8]
Formula:
C19H21ClN6O3
Target:
LRRK2
Application Notes:
Reference compound
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