DKK-3 Protein, Human (R335G, HEK293, His),Human,HEK293
DKK-3 protein antagonizes canonical Wnt signaling by blocking LRP5/6-Wnt interactions and forming a ternary complex with KREMEN, thereby promoting LRP5/6 internalization. In vertebrate development, DKK-3, together with other DKKs, critically inhibits Wnt