4 -DTMP is a DHFR inhibitor with Ki of 5.1 nM (DHFRWT) and 34.3 nM (DHFRL28R), respectively. 4 -DTMP carries a polar modification that induces additional local interactions with the enzyme. In particular, the hairpin structure on the M20 ring is related
Molecular Weight:
276.29
Purity:
97
CAS Number:
[21253-58-7]
Formula:
C13H16N4O3
Target:
Dihydrofolate reductase (DHFR)
Application Notes:
Reference compound
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