MGMT (Marker of Suppressor of Mutation and Carcinogenesis) Antibody, Clone: [MGMT/8364R], Rabbit, Monoclonal

Product Overview

• Article Name: MGMT (Marker of Suppressor of Mutation and Carcinogenesis) Antibody, Clone: [MGMT/8364R], Rabbit, Monoclonal
• Biozol Catalog Number: NBT-4255-RBM11-P0
• Supplier Catalog Number: 4255-RBM11-P0
• Alternative Catalog Number: NBT-4255-RBM11-P0-20,NBT-4255-RBM11-P0-100
• Manufacturer: NeoBiotechnologies
• Host: Rabbit
• Category: Antikörper
• Application: IHC
• Species Reactivity: Human
• Immunogen: Recombinant fragment (around aa1-100) of human MGMT (exact sequence is proprietary)
• Alternative Names: 6 O methylguanine DNA methyltransferase, Methylated DNA protein cysteine methyltransferase, O 6 methylguanine DNA alkyltransferase, O 6 methylguanine DNA methyltransferase

Product Description

Cancer chemotherapeutic alkylating agents (e.g. BCNU,) act by inducing formation of lethal crossa links at the O6a alkylguanine position in DNA. MGMT transfers alkyl adducts from the O6a position of guanine in DNA (prior to crossa link forma

Product Properties

• Clonality: Monoclonal
• Clone Designation: [MGMT/8364R]
• Molecular Weight: 21.646 kDa
• NCBI: 4255
• UniProt: P16455
• Form: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Antibody Type: Monoclonal Antibody

Application Notes

• Application Notes: Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95&degC followed by cooling at RT for 20 minutes),Optimal dilutio