Synthetic peptide derived from the human SIAH-1 protein.
Alternative Names:
SIAH1 (seven in absentia homolog 1), E3 Ubiquitin Ligase
Seven in absentia homolog 1 (SIAH-1) is a member of the RING-finger-containing E3 ubiquitin ligases. Alpha-synuclein and synphilin-1 are substrates of SIAH-1. Both proteins are involved in the development of Parkinsons disease (PD). Mutations in Parkin,