A recombinant fragment (within amino acids 100-250) of human PRAME protein was used as the immunogen for the PRAME antibody.
Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. This gene encodes an ant