Cucurbitacin IIb (CuIIb, Dihydrocucurbitacin F, 25-deacetyl hemslecin A) inhibits phosphorylation of STAT3, JNK and Erk1/2, enhances the phosphorylation of IkappaB and NF-kappaB, blocks nuclear translocation of NF-kappaB and decreases mRNA levels of IkappaBalpha and TNF-alpha.
CAS Number:
[50298-90-3]
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