Dooku1 is an analog of Yoda1 and a selective antagonist of endogenous Piezo1 channels. Dooku1 inhibits Ca2+ entry induced by 2µMYoda1 with IC50 values of 1.3µM (in HEK 293 cells) and 1.5µM (in HUVEC). Dooku1 inhibits Yoda1-induced aortic relaxation.
Molecular Weight:
326.2
CAS Number:
[2253744-54-4]
Formula:
C13H9Cl2N3OS
Target:
Piezo Channel
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