STING18 is a competitive ligand of stimulator of interferon genes (STING, IC50 = 0.068 µM in a radioligand binding assay).1 It inhibits cGAMP-induced IFN-beta production (IC50 = 11 µM) but does not stimulate IFN-beta production (EC50 = >30 µM) in THP-1 cells.
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