Dot1L-IN-1 TFA is a potent and selective Dot1L inhibitor, characterized by a K i of 2 pM and an IC 50 of <0.1 nM. It effectively inhibits H3K79 dimethylation (IC 50 =3 nM) and suppresses the HoxA9 promoter activity (IC 50 =17 nM) in HeLa and Molm-13 cell
Molecular Weight:
760.23
Formula:
C34H37ClF3N9O4S
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