AD4, an artemisinin derivative functioning as a proteolytic targeting chimera (PROTAC) for PCLAF, effectively degrades PCLAF in RS4,11 cells with an IC50 of 0.6 nM. This degradation activates the p21/Rb axis, resulting in antitumor activity. Furthermore,
Molecular Weight:
1035.23
CAS Number:
[2918262-09-4]
Formula:
C55H78N4O15
Target:
PROTACs|||Others
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