TRK-IN-23 (compound 24b) is a potent, orally active inhibitor of TRK with IC50s of 0.5 nM for TRKA, 9 nM for TRKC, 14 nM for TRKA G595R, 4.4 nM for TRKA F589L, and 4.8 nM for TRKA G667C. It induces apoptosis in Ba/F3-TRKAG595R and Ba/F3-TRKAG667C cells [
Molecular Weight:
364.37
CAS Number:
[2924344-29-4]
Formula:
C20H17FN4O2
Target:
Trk receptor
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